The first church was built at the end of the 3rd or in the first half of the 4th century. It was built on the ruins of a Roman temple, probably dedicated to Minerva Chalcidia.
The present church dates to c. 1280, and became an important church for the Dominicans. The architects were probably Fra Sisto and Fra Ristoro of Arezzo, and the work was ordered by Pope Nicholas III
In the 17th century, Carlo Maderno
renovated the church.
It has been renovated several times, with the last major work done in the 19th century by Fra Girolamo Bianchedi.