The barrel-vaulted ceiling is, like the ceiling of the nave, decorated with frescoes by Domenico Maria Canuti and Enrico Haffner in 1674-75. They represent:
Virgin Mary protects Dominican-Order (vault)
Christ reveals himself to San Domenico and the Dominican Nuns (back wall)
and, in oval stucco frames on the sides:
Pope Honorius III surrenders Order approval for San Domenico
Virgin Mary appears to San Domenico.