The chapel is at the rear of the left hand aisle. The chapel was commissioned by Cardinal Branda da Castiglione. Work on the chapel is estimated to have taken place between 1428 and 1431. It in the Gothic style, rather unusual in Rome, and is entirely covered in beautiful early Renaissance (Quattrocento) frescoes which are among the most important of the period in Rome. These paintings are attributed to Masolino da Panicale di Valdelsa.